What is the most likely diagnosis?
- 42 year-old found unresponsive in morning
Two images from Unenhanced CT of Brain
- Cerebral aneurysm
- Bilateral subdural hematomas
- Transtentorial herniation
- Diffuse Axonal Injury
- Carbon Monoxide Poisoning
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Answer:
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5. Carbon Monoxide Poisoning
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Carbon Monoxide Poisoning
General Considerations
- Leading cause of accidental poisoning deaths in the United States
- Most fatalities result from fires, malfunctioning stoves, exhaust systems, heaters, suicide attempts
- Impairs oxygen delivery and has its most lethal effects on organs requiring high levels of oxygen, i.e. the brain and heart
- Binds reversibly to hemoglobin much more avidly than oxygen (200-250 times more avidly) leading to high levels of carboxyhemoglobin
- It also binds to myoglobin with an even greater affinity than to hemoglobin
- Populations at risk for mortality are those over the age of 75, those with underlying cardiopulmonary disorders, neonates and the fetus in utero
- Pathology in brain
- White matter demyelination
- Edema and necrosis bilaterally in the globus pallidus, caudate nucleus and cerebellum
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